Expression of VGLL3 in cancer - Summary - The Human Protein Atlas

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VGLL3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	VGLL3
Gene description	Vestigial-like family member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (prostate cancer)
HPA (cell line):	Cell line enriched (U-2197)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in a subset of trophoblastic cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Cytoplasmic/membranous binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA054983
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA054983

GENE INFORMATION
Gene name	VGLL3 (HGNC Symbol)
Synonyms	VGL-3
Description	Vestigial-like family member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p12.1
Chromosome location (bp)	86937969 - 86991119
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000206538 (version 83.38)
Entrez gene	389136
UniProt	A8MV65 (UniProt - Evidence at transcript level)
neXtProt	NX_A8MV65
Antibodypedia	VGLL3 antibodies

PROTEIN BROWSER

VGLL3-001	VGLL3-002	VGLL3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VGLL3-001 ENSP00000381436 ENST00000398399	A8MV65 [Direct mapping] Transcription cofactor vestigial-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008022 [protein C-terminus binding] Show all	326 aa 36 kDa	No	0
VGLL3-002 ENSP00000373199 ENST00000383698	A8MV65 [Direct mapping] Transcription cofactor vestigial-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	320 aa 35.2 kDa	No	0
VGLL3-003 ENSP00000419115 ENST00000494229	H7C571 [Direct mapping] Transcription cofactor vestigial-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	209 aa 22.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.