Expression of XKR4 in cancer - Summary - The Human Protein Atlas

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XKR4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	XKR4
Gene description	XK, Kell blood group complex subunit-related family, member 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Group enriched (REH, RPTEC TERT1)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA025072 , HPA028083
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA025072	HPA028083

GENE INFORMATION
Gene name	XKR4 (HGNC Symbol)
Synonyms	KIAA1889
Description	XK, Kell blood group complex subunit-related family, member 4 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q12.1
Chromosome location (bp)	55102389 - 55542054
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000206579 (version 83.38)
Entrez gene	114786
UniProt	Q5GH76 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5GH76
Antibodypedia	XKR4 antibodies

PROTEIN BROWSER

XKR4-001	XKR4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
XKR4-001 ENSP00000328326 ENST00000327381	Q5GH76 [Direct mapping] XK-related protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	650 aa 71.5 kDa	No	9
XKR4-201 ENSP00000480076 ENST00000622811	Q5GH76 [Direct mapping] XK-related protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	650 aa 71.5 kDa	No	9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.