Expression of GPX3 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GPX3
Gene description	Glutathione peroxidase 3
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CACO-2, EFO-21, Hep G2)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nucleus expression in most tissues, additional plasma positivity in a few.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. CAB069456
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (unfavourable).
Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

CAB069456

GENE INFORMATION
Gene name	GPX3
Synonyms
Description	Glutathione peroxidase 3 (HGNC Symbol)
Entrez gene summary	This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q33.1
Chromosome location (bp)	151020438 - 151028993
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000211445 (version 83.38)
Entrez gene	2878
UniProt	P22352 (UniProt - Evidence at protein level)
neXtProt	NX_P22352
Antibodypedia	GPX3 antibodies

PROTEIN BROWSER

GPX3-001	GPX3-003	GPX3-004	GPX3-008	GPX3-010	GPX3-201	GPX3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPX3-001 ENSP00000373477 ENST00000388825	P22352 [Direct mapping] Glutathione peroxidase 3 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000302 [response to reactive oxygen species] GO:0004602 [glutathione peroxidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006979 [response to oxidative stress] GO:0006982 [response to lipid hydroperoxide] GO:0008134 [transcription factor binding] GO:0008430 [selenium binding] GO:0042744 [hydrogen peroxide catabolic process] GO:0051289 [protein homotetramerization] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	226 aa 25.6 kDa	Yes	0
GPX3-003 ENSP00000430743 ENST00000521632	H0YC19 [Direct mapping] Glutathione peroxidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	174 aa 18.9 kDa	No	0
GPX3-004 ENSP00000427873 ENST00000521650	E5RG32 [Direct mapping] Glutathione peroxidase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	139 aa 15.2 kDa	Yes	0
GPX3-008 ENSP00000429314 ENST00000520059	H0YBE4 [Direct mapping] Glutathione peroxidase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	79 aa 8.7 kDa	No	0
GPX3-010 ENSP00000429709 ENST00000517973	E5RHK5 [Direct mapping] Glutathione peroxidase 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		100 aa 11.4 kDa	Yes	0
GPX3-201 ENSP00000483660 ENST00000614343	Q6NXQ3 [Direct mapping] GPX3 protein; Glutathione peroxidase 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	72 aa 7.9 kDa	Yes	0
GPX3-202 ENSP00000484258 ENST00000622181	A0A087X1J7 [Direct mapping] Glutathione peroxidase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	225 aa 25.4 kDa	Yes	0