Expression of DIO2 in cancer - Summary - The Human Protein Atlas

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DIO2

TISSUE

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CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	DIO2
Gene description	Deiodinase, iodothyronine, type II
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (thyroid cancer)
HPA (cell line):	Cell line enhanced (BJ, HeLa, SiHa)
HPA (normal tissue):	Group enriched (cervix, uterine, thyroid gland)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and colorectal cancer (favourable).
Endometrial cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	DIO2 (HGNC Symbol)
Synonyms	SelY, TXDI2
Description	Deiodinase, iodothyronine, type II (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q31.1
Chromosome location (bp)	80197527 - 80387757
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000211448 (version 83.38)
Entrez gene	1734
UniProt	Q92813 (UniProt - Evidence at protein level)
neXtProt	NX_Q92813
Antibodypedia	DIO2 antibodies

PROTEIN BROWSER

DIO2-001	DIO2-002	DIO2-003	DIO2-004	DIO2-006	DIO2-007	DIO2-009	DIO2-010	DIO2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DIO2-001 ENSP00000451419 ENST00000557010	Q92813 [Direct mapping] Type II iodothyronine deiodinase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001514 [selenocysteine incorporation] GO:0004800 [thyroxine 5'-deiodinase activity] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0008430 [selenium binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042403 [thyroid hormone metabolic process] GO:0042446 [hormone biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	273 aa 30.6 kDa	No	1
DIO2-002 ENSP00000405854 ENST00000438257	Q92813 [Direct mapping] Type II iodothyronine deiodinase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001514 [selenocysteine incorporation] GO:0004800 [thyroxine 5'-deiodinase activity] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0008430 [selenium binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042403 [thyroid hormone metabolic process] GO:0042446 [hormone biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	273 aa 30.6 kDa	No	1
DIO2-003 ENSP00000450980 ENST00000555750	A0A0A0MTQ2 [Direct mapping] Iodothyronine deiodinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0042404 [thyroid hormone catabolic process] GO:0042446 [hormone biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	309 aa 34.8 kDa	No	1
DIO2-004 ENSP00000451971 ENST00000556811	H0YJQ8 [Direct mapping] Type II iodothyronine deiodinase Show all	Predicted intracellular proteins Show all		58 aa 6.5 kDa	No	0
DIO2-006 ENSP00000451136 ENST00000554188	G3V3A8 [Direct mapping] Iodothyronine deiodinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0016021 [integral component of membrane] GO:0042446 [hormone biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	55 aa 6.3 kDa	No	1
DIO2-007 ENSP00000451265 ENST00000553594		Predicted intracellular proteins Show all		6 aa 0.6 kDa	No	0
DIO2-009 ENSP00000451339 ENST00000553968		Predicted intracellular proteins Show all		6 aa 0.6 kDa	No	0
DIO2-010 ENSP00000450547 ENST00000557125	G3V2A7 [Direct mapping] Type II iodothyronine deiodinase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		56 aa 6.5 kDa	Yes	0
DIO2-201 ENSP00000411438 ENST00000422005	J3KQY5 [Direct mapping] Iodothyronine deiodinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0042446 [hormone biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	145 aa 16.6 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.