Expression of C11orf31 in cancer - Summary - The Human Protein Atlas

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C11orf31

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C11orf31
Gene description	Chromosome 11 open reading frame 31
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA048362
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable) and liver cancer (unfavourable).
Ovarian cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048362

GENE INFORMATION
Gene name	C11orf31 (HGNC Symbol)
Synonyms	SELH
Description	Chromosome 11 open reading frame 31 (HGNC Symbol)
Entrez gene summary	This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. The exact function of this gene is not known, however, selenoproteins are thought to be responsible for most biomedical effects of dietary selenium. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.1
Chromosome location (bp)	57741250 - 57743554
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000211450 (version 83.38)
Entrez gene	280636
UniProt	Q8IZQ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZQ5
Antibodypedia	C11orf31 antibodies

PROTEIN BROWSER

C11orf31-001	C11orf31-004	C11orf31-005	C11orf31-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C11orf31-001 ENSP00000434511 ENST00000534355	Q8IZQ5 [Direct mapping] Selenoprotein H Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0044822 [poly(A) RNA binding] Show all	122 aa 13.5 kDa	No	0
C11orf31-004 ENSP00000373509 ENST00000388857	Q8IZQ5 [Direct mapping] Selenoprotein H Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0044822 [poly(A) RNA binding] Show all	122 aa 13.5 kDa	No	0
C11orf31-005 ENSP00000434875 ENST00000528798	H0YE28 [Direct mapping] Selenoprotein H Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10.4 kDa	No	0
C11orf31-201 ENSP00000481984 ENST00000622257	A0A087WYP2 [Direct mapping] Selenoprotein H Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 13.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.