Expression of KRTAP3-3 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

KRTAP3-3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRTAP3-3
Gene description	Keratin associated protein 3-3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (urothelial cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expressed in the internal root sheath of hair.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. External characterization data supports antibody staining pattern while RNA data does not.
Reliability score	Approved based on 1 antibody. HPA042992
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042992

GENE INFORMATION
Gene name	KRTAP3-3 (HGNC Symbol)
Synonyms	KAP3.3
Description	Keratin associated protein 3-3 (HGNC Symbol)
Entrez gene summary	This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	40993430 - 40994133
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000212899 (version 83.38)
Entrez gene	85293
UniProt	Q9BYR6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYR6
Antibodypedia	KRTAP3-3 antibodies

PROTEIN BROWSER

KRTAP3-3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRTAP3-3-001 ENSP00000375428 ENST00000391586	Q9BYR6 [Direct mapping] Keratin-associated protein 3-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0045095 [keratin filament] Show all	98 aa 10.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.