Expression of KLK9 in cancer - Summary - The Human Protein Atlas

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KLK9

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KLK9
Gene description	Kallikrein-related peptidase 9
Protein class	Cancer-related genes Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (head and neck cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification.
Reliability score	Uncertain based on 1 antibody. CAB025049
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB025049

GENE INFORMATION
Gene name	KLK9 (HGNC Symbol)
Synonyms	KLK-L3
Description	Kallikrein-related peptidase 9 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010]
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	51003111 - 51009634
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000213022 (version 83.38)
Entrez gene	284366
UniProt	Q9UKQ9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UKQ9
Antibodypedia	KLK9 antibodies

PROTEIN BROWSER

KLK9-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLK9-002 ENSP00000469417 ENST00000594211	Q9UKQ9 [Direct mapping] Kallikrein-9 Q2XQG6 [Target identity:100%; Query identity:100%] Kallikrein 9; Kallikrein 9, isoform CRA_b Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] Show all	250 aa 27.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.