Cell atlas - CGB8 - The Human Protein Atlas

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CGB8

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	CGB8
Gene description	Chorionic gonadotropin, beta polypeptide 8
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Group enriched (BEWO, U-251 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA038925 , HPA038934
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (BEWO, U-251 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA038925	A-431	Cytosol
HPA038925	U-2 OS	Cytosol
HPA038934	A-431	Cytosol
HPA038934	U-2 OS	Cytosol
HPA038934	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CGB8
Synonyms
Description	Chorionic gonadotropin, beta polypeptide 8 (HGNC Symbol)
Entrez gene summary	This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49047638 - 49049106
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213030 (version 83.38)
Entrez gene	94115
UniProt	P01233 (UniProt - Evidence at protein level)
neXtProt	NX_P01233
Antibodypedia	CGB8 antibodies

PROTEIN BROWSER

CGB8-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CGB8-001 ENSP00000403649 ENST00000448456	P01233 [Direct mapping] Choriogonadotropin subunit beta A0A0F7RQP8 [Target identity:100%; Query identity:100%] Chorionic gonadotropin beta subunit 3; Chorionic gonadotropin beta subunit 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0007292 [female gamete generation] GO:0016486 [peptide hormone processing] GO:0044267 [cellular protein metabolic process] Show all	165 aa 17.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.