Expression of DENND1B in cancer - Summary - The Human Protein Atlas

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DENND1B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DENND1B
Gene description	DENN/MADD domain containing 1B
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA042586
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042586

GENE INFORMATION
Gene name	DENND1B (HGNC Symbol)
Synonyms	C1orf218, FAM31B, FLJ20054, MGC27044
Description	DENN/MADD domain containing 1B (HGNC Symbol)
Entrez gene summary	Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Chromosome	1
Cytoband	q31.3
Chromosome location (bp)	197504748 - 197775696
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213047 (version 83.38)
Entrez gene	163486
UniProt	Q6P3S1 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P3S1
Antibodypedia	DENND1B antibodies

PROTEIN BROWSER

DENND1B-001	DENND1B-003	DENND1B-004	DENND1B-010	DENND1B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DENND1B-001 ENSP00000375839 ENST00000391979	X6RAS2 [Direct mapping] DENN domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		415 aa 45.8 kDa	No	0
DENND1B-003 ENSP00000356366 ENST00000367396	Q6P3S1 [Direct mapping] DENN domain-containing protein 1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0015031 [protein transport] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0030136 [clathrin-coated vesicle] GO:0043547 [positive regulation of GTPase activity] Show all	426 aa 48.3 kDa	No	1
DENND1B-004 ENSP00000235453 ENST00000235453	Q6P3S1 [Direct mapping] DENN domain-containing protein 1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0015031 [protein transport] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0030136 [clathrin-coated vesicle] GO:0043547 [positive regulation of GTPase activity] Show all	396 aa 44.9 kDa	No	1
DENND1B-010 ENSP00000410025 ENST00000422998	B7ZBL5 [Direct mapping] DENN domain-containing protein 1B Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		147 aa 16.9 kDa	No	0
DENND1B-201 ENSP00000479816 ENST00000620048	Q6P3S1 [Direct mapping] DENN domain-containing protein 1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0015031 [protein transport] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0030136 [clathrin-coated vesicle] GO:0043547 [positive regulation of GTPase activity] Show all	775 aa 86.6 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.