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This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0006469 [negative regulation of protein kinase activity] GO:0006996 [organelle organization] GO:0008284 [positive regulation of cell proliferation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019901 [protein kinase binding] GO:0030292 [protein tyrosine kinase inhibitor activity] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0034453 [microtubule anchoring] GO:0042803 [protein homodimerization activity] GO:0048471 [perinuclear region of cytoplasm] GO:0061099 [negative regulation of protein tyrosine kinase activity]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0006469 [negative regulation of protein kinase activity] GO:0006996 [organelle organization] GO:0008284 [positive regulation of cell proliferation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019901 [protein kinase binding] GO:0030292 [protein tyrosine kinase inhibitor activity] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0034453 [microtubule anchoring] GO:0042803 [protein homodimerization activity] GO:0048471 [perinuclear region of cytoplasm] GO:0061099 [negative regulation of protein tyrosine kinase activity]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
