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CRIP1

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GENERAL INFORMATION

Gene name

 CRIP1

Gene description

 Cysteine-rich protein 1 (intestinal)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the centrosome & nuclear speckles. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (A549, T-47d, HaCaT, CAPAN-2, HDLM-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (uncertain), Centrosome (uncertain)

Additional location

 In addition localized to the Cytosol (uncertain)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA042462
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A549, T-47d, HaCaT, CAPAN-2, HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the centrosome & nuclear speckles. In addition localized to the cytosol.

Main location

 Nuclear speckles (uncertain), Centrosome (uncertain)

Additional location

 Cytosol (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA042462 A549 Nuclear speckles
Plasma membrane
Centrosome
Cytosol
HPA042462 HaCaT Nuclear speckles
Plasma membrane
Centrosome
HPA042462 U-2 OS Nuclear speckles
Centrosome
Cytosol

GENE INFORMATION

Gene name

 CRIP1 (HGNC Symbol)

Synonyms

 CRIP

Description

 Cysteine-rich protein 1 (intestinal) (HGNC Symbol)

Entrez gene summary

 Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]

Chromosome

 14

Cytoband

 q32.33

Chromosome location (bp)

 105486317 - 105488947

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213145 (version 83.38)

Entrez gene

 1396

UniProt

 P50238 (UniProt - Evidence at protein level)

neXtProt

 NX_P50238

Antibodypedia

 CRIP1 antibodies

PROTEIN BROWSER
CRIP1-001
CRIP1-002
CRIP1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRIP1-001
ENSP00000386340
ENST00000409393
P50238 [Direct mapping]
Cysteine-rich protein 1
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Predicted intracellular proteins
Plasma proteins
Show all
GO:0003680 [AT DNA binding]
GO:0005737 [cytoplasm]
GO:0006955 [immune response]
GO:0007507 [heart development]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008301 [DNA binding, bending]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010033 [response to organic substance]
GO:0010043 [response to zinc ion]
GO:0010468 [regulation of gene expression]
GO:0042277 [peptide binding]
GO:0060741 [prostate gland stromal morphogenesis]
GO:0071236 [cellular response to antibiotic]
GO:0071493 [cellular response to UV-B]
Show all
 77 aa
8.5 kDa 		No 0
CRIP1-002
ENSP00000376315
ENST00000392531
P50238 [Direct mapping]
Cysteine-rich protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003680 [AT DNA binding]
GO:0005737 [cytoplasm]
GO:0006955 [immune response]
GO:0007507 [heart development]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008301 [DNA binding, bending]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010033 [response to organic substance]
GO:0010043 [response to zinc ion]
GO:0010468 [regulation of gene expression]
GO:0042277 [peptide binding]
GO:0060741 [prostate gland stromal morphogenesis]
GO:0071236 [cellular response to antibiotic]
GO:0071493 [cellular response to UV-B]
Show all
 77 aa
8.5 kDa 		No 0
CRIP1-006
ENSP00000332449
ENST00000330233
P50238 [Direct mapping]
Cysteine-rich protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0003680 [AT DNA binding]
GO:0005737 [cytoplasm]
GO:0006955 [immune response]
GO:0007507 [heart development]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008301 [DNA binding, bending]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010033 [response to organic substance]
GO:0010043 [response to zinc ion]
GO:0010468 [regulation of gene expression]
GO:0042277 [peptide binding]
GO:0060741 [prostate gland stromal morphogenesis]
GO:0071236 [cellular response to antibiotic]
GO:0071493 [cellular response to UV-B]
Show all
 77 aa
8.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.