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Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (HGNC Symbol)
Entrez gene summary
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]
Q13015 [Direct mapping] Protein AF1q Q6FGF7 [Target identity:100%; Query identity:100%] AF1Q protein; Myeloid/lymphoid or mixed-lineage leukemia (Trithorax homolog, Drosophila) translocated to, 11; cDNA FLJ31527 fis, clone NT2RI2000344, highly similar to Protein AF1q
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Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0043065 [positive regulation of apoptotic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0051901 [positive regulation of mitochondrial depolarization] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097193 [intrinsic apoptotic signaling pathway]
