Expression of MXD3 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MXD3

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	MXD3
Gene description	MAX dimerization protein 3
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (bone marrow)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	MXD3 (HGNC Symbol)
Synonyms	bHLHc13, MAD3
Description	MAX dimerization protein 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	177301461 - 177312757
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213347 (version 83.38)
Entrez gene	83463
UniProt	Q9BW11 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BW11
Antibodypedia	MXD3 antibodies

PROTEIN BROWSER

MXD3-001	MXD3-002	MXD3-003	MXD3-006	MXD3-008	MXD3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MXD3-001 ENSP00000401867 ENST00000439742	Q9BW11 [Direct mapping] Max dimerization protein 3 A0A024R7S0 [Target identity:100%; Query identity:100%] MAX dimerization protein 3, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	206 aa 23.5 kDa	No	0
MXD3-002 ENSP00000389716 ENST00000423571	Q9BW11 [Direct mapping] Max dimerization protein 3 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	388 aa 42.8 kDa	No	0
MXD3-003 ENSP00000416921 ENST00000427908	Q9BW11 [Direct mapping] Max dimerization protein 3 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	193 aa 22.1 kDa	No	0
MXD3-006 ENSP00000425029 ENST00000502529	D6RED4 [Direct mapping] Max dimerization protein 3 Show all	Predicted intracellular proteins Show all	GO:0046983 [protein dimerization activity] Show all	124 aa 14.5 kDa	No	0
MXD3-008 ENSP00000427104 ENST00000513169	D6RD21 [Direct mapping] Max dimerization protein 3 Show all	Predicted intracellular proteins Show all	GO:0046983 [protein dimerization activity] Show all	75 aa 8.7 kDa	No	0
MXD3-009 ENSP00000421463 ENST00000513063	Q9BW11 [Direct mapping] Max dimerization protein 3 A0A024R7S0 [Target identity:100%; Query identity:100%] MAX dimerization protein 3, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	206 aa 23.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.