Expression of COG8 in cancer - Summary - The Human Protein Atlas

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COG8

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COG8
Gene description	Component of oligomeric golgi complex 8
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA041406
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041406

GENE INFORMATION
Gene name	COG8 (HGNC Symbol)
Synonyms	DOR1, FLJ22315
Description	Component of oligomeric golgi complex 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	69320140 - 69339667
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213380 (version 83.38)
Entrez gene	84342
UniProt	Q96MW5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96MW5
Antibodypedia	COG8 antibodies

PROTEIN BROWSER

COG8-001	COG8-002	COG8-003	COG8-006	COG8-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COG8-001 ENSP00000305459 ENST00000306875	Q96MW5 [Direct mapping] Conserved oligomeric Golgi complex subunit 8 A0A024R6Z6 [Target identity:100%; Query identity:100%] HCG2027080, isoform CRA_b Show all	THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0006891 [intra-Golgi vesicle-mediated transport] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0017119 [Golgi transport complex] Show all	612 aa 68.4 kDa	No	0
COG8-002 ENSP00000464395 ENST00000567493	J3QRV3 [Direct mapping] Conserved oligomeric Golgi complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017119 [Golgi transport complex] Show all	99 aa 11.7 kDa	No	0
COG8-003 ENSP00000455954 ENST00000562081	H3BQV3 [Direct mapping] Conserved oligomeric Golgi complex subunit 8 Show all	THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017119 [Golgi transport complex] Show all	534 aa 60.4 kDa	No	0
COG8-006 ENSP00000456705 ENST00000562595	H3BSH5 [Direct mapping] Conserved oligomeric Golgi complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017119 [Golgi transport complex] Show all	223 aa 25.6 kDa	No	0
COG8-007 ENSP00000484442 ENST00000615447	A0A087X1T3 [Direct mapping] Conserved oligomeric Golgi complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017119 [Golgi transport complex] Show all	121 aa 13.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.