Cell atlas - ARHGAP19 - The Human Protein Atlas

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ARHGAP19

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane
	Vesicles

Human cell
	Plasma Membrane
	Vesicles

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GENERAL INFORMATION
Gene name	ARHGAP19
Gene description	Rho GTPase activating protein 19
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Vesicles (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA035777 , HPA043231
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA035777	RH-30	Plasma membrane	Intensity
HPA035777	U-2 OS	Plasma membrane
HPA043231	A-431	Vesicles
HPA043231	A-431	Plasma membrane
HPA043231	RH-30	No staining
HPA043231	U-2 OS	Vesicles
HPA043231	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	ARHGAP19 (HGNC Symbol)
Synonyms	FLJ00194, MGC14258
Description	Rho GTPase activating protein 19 (HGNC Symbol)
Entrez gene summary	Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]
Chromosome	10
Cytoband	q24.1
Chromosome location (bp)	97222173 - 97292673
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213390 (version 83.38)
Entrez gene	84986
UniProt	Q14CB8 (UniProt - Evidence at protein level)
neXtProt	NX_Q14CB8
Antibodypedia	ARHGAP19 antibodies

PROTEIN BROWSER

ARHGAP19-002	ARHGAP19-003	ARHGAP19-006	ARHGAP19-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGAP19-002 ENSP00000360066 ENST00000371027	Q14CB8 [Direct mapping] Rho GTPase-activating protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	485 aa 54.9 kDa	No	0
ARHGAP19-003 ENSP00000351333 ENST00000358531	Q14CB8 [Direct mapping] Rho GTPase-activating protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	494 aa 55.8 kDa	No	0
ARHGAP19-006 ENSP00000473667 ENST00000466484	R4GNI4 [Direct mapping] Rho GTPase-activating protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	197 aa 22.2 kDa	No	0
ARHGAP19-201 ENSP00000351058 ENST00000358308	Q14CB8 [Direct mapping] Rho GTPase-activating protein 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	465 aa 52.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.