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LCAT

GENERAL INFORMATION

Gene name

 LCAT

Gene description

 Lecithin-cholesterol acyltransferase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BEWO)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable), renal cancer (unfavourable) and colorectal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 LCAT

Synonyms

Description

 Lecithin-cholesterol acyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 67939750 - 67944131

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213398 (version 83.38)

Entrez gene

 3931

UniProt

 P04180 (UniProt - Evidence at protein level)

neXtProt

 NX_P04180

Antibodypedia

 LCAT antibodies

PROTEIN BROWSER
LCAT-001
LCAT-004
LCAT-008
LCAT-011
LCAT-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LCAT-001
ENSP00000264005
ENST00000264005
P04180 [Direct mapping]
Phosphatidylcholine-sterol acyltransferase
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004607 [phosphatidylcholine-sterol O-acyltransferase activity]
GO:0004623 [phospholipase A2 activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0008203 [cholesterol metabolic process]
GO:0008374 [O-acyltransferase activity]
GO:0030301 [cholesterol transport]
GO:0034186 [apolipoprotein A-I binding]
GO:0034364 [high-density lipoprotein particle]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034435 [cholesterol esterification]
GO:0042157 [lipoprotein metabolic process]
GO:0042158 [lipoprotein biosynthetic process]
GO:0042632 [cholesterol homeostasis]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0046688 [response to copper ion]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:0090107 [regulation of high-density lipoprotein particle assembly]
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 440 aa
49.6 kDa 		Yes 0
LCAT-004
ENSP00000464651
ENST00000570980
J3QSE5 [Direct mapping]
Phosphatidylcholine-sterol acyltransferase
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   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006629 [lipid metabolic process]
GO:0008374 [O-acyltransferase activity]
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 255 aa
29.4 kDa 		No 0
LCAT-008
ENSP00000459014
ENST00000570369
I3L1Q6 [Direct mapping]
Phosphatidylcholine-sterol acyltransferase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006629 [lipid metabolic process]
GO:0008374 [O-acyltransferase activity]
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 107 aa
10.9 kDa 		No 0
LCAT-011
ENSP00000458141
ENST00000576450
I3L0J6 [Direct mapping]
Phosphatidylcholine-sterol acyltransferase
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   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006629 [lipid metabolic process]
GO:0008374 [O-acyltransferase activity]
GO:0016021 [integral component of membrane]
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 80 aa
8.8 kDa 		No 0
LCAT-012
ENSP00000459291
ENST00000570396
I3L215 [Direct mapping]
Phosphatidylcholine-sterol acyltransferase
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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 61 aa
6.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.