Expression of KRTAP2-4 in cancer - Summary - The Human Protein Atlas

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KRTAP2-4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRTAP2-4
Gene description	Keratin associated protein 2-4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in hair cortex.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Antibody staining consistent with external characterization data and GTEx RNA expression data.
Reliability score	Supported based on 1 antibody. HPA059203
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059203

GENE INFORMATION
Gene name	KRTAP2-4 (HGNC Symbol)
Synonyms	KAP2.4
Description	Keratin associated protein 2-4 (HGNC Symbol)
Entrez gene summary	This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	41065116 - 41065879
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213417 (version 83.38)
Entrez gene	85294
UniProt	Q9BYR9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BYR9
Antibodypedia	KRTAP2-4 antibodies

PROTEIN BROWSER

KRTAP2-4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRTAP2-4-001 ENSP00000377583 ENST00000394015	Q9BYR9 [Direct mapping] Keratin-associated protein 2-4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0045095 [keratin filament] Show all	128 aa 13.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.