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GPC2

GENERAL INFORMATION

Gene name

 GPC2

Gene description

 Glypican 2

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AF22, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (skin, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
CAB025423
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB025423

GENE INFORMATION

Gene name

 GPC2 (HGNC Symbol)

Synonyms

 cerebroglycan, DKFZp547M109, FLJ38962

Description

 Glypican 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100169606 - 100177372

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213420 (version 83.38)

Entrez gene

 221914

UniProt

 Q8N158 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8N158

Antibodypedia

 GPC2 antibodies

PROTEIN BROWSER
GPC2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPC2-001
ENSP00000292377
ENST00000292377
Q8N158 [Direct mapping]
Glypican-2 Secreted glypican-2
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   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001523 [retinoid metabolic process]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0007224 [smoothened signaling pathway]
GO:0007603 [phototransduction, visible light]
GO:0016020 [membrane]
GO:0030182 [neuron differentiation]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0031225 [anchored component of membrane]
GO:0043202 [lysosomal lumen]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0044281 [small molecule metabolic process]
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 579 aa
62.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.