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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SYNJ2BP
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SYNJ2BP

Gene description

Synaptojanin 2 binding protein

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression, most abundant in gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

Approved based on 1 antibody.
HPA000866
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA000866

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of tumors displayed moderate cytoplasmic positivity with a granular pattern. Strongest staining was observed in prostate and liver cancers, while lymphomas, gliomas and squamous cell carcinomas generally were negative.

GENE INFORMATION

Gene name

SYNJ2BP (HGNC Symbol)

Synonyms

Arip2

Description

Synaptojanin 2 binding protein (HGNC Symbol)

Entrez gene summary

Chromosome

14

Cytoband

q24.2

Chromosome location (bp)

70366496 - 70417061

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000213463 (version 83.38)

Entrez gene

55333

UniProt

P57105 (UniProt - Evidence at protein level)

neXtProt

NX_P57105

Antibodypedia

SYNJ2BP antibodies

PROTEIN BROWSER

SYNJ2BP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SYNJ2BP-001
ENSP00000256366
ENST00000256366
P57105 [Direct mapping]
Synaptojanin-2-binding protein
A0A024R670 [Target identity:100%; Query identity:100%]
Synaptojanin 2 binding protein, isoform CRA_a
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006605 [protein targeting]
GO:0007266 [Rho protein signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009986 [cell surface]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0016021 [integral component of membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0030100 [regulation of endocytosis]
GO:0031307 [integral component of mitochondrial outer membrane]
GO:0032926 [negative regulation of activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0048312 [intracellular distribution of mitochondria]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070699 [type II activin receptor binding]
GO:1903671 [negative regulation of sprouting angiogenesis]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
145 aa
15.9 kDa
No 1

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