Fields »
ABOUT
HELP
BLOG
ARL2

GENERAL INFORMATION

Gene name

 ARL2

Gene description

 ADP-ribosylation factor-like 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA044610
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and prostate cancer (favourable).
Endometrial cancer p<0.001
Prostate cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044610

GENE INFORMATION

Gene name

 ARL2 (HGNC Symbol)

Synonyms

 ARFL2

Description

 ADP-ribosylation factor-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65014113 - 65022184

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213465 (version 83.38)

Entrez gene

 402

UniProt

 P36404 (UniProt - Evidence at protein level)

neXtProt

 NX_P36404

Antibodypedia

 ARL2 antibodies

PROTEIN BROWSER
ARL2-001
ARL2-003
ARL2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARL2-001
ENSP00000246747
ENST00000246747
P36404 [Direct mapping]
ADP-ribosylation factor-like protein 2
Q53YD8 [Target identity:100%; Query identity:100%]
ADP-ribosylation factor-like 2; ADP-ribosylation factor-like 2 variant; HCG23373, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006112 [energy reserve metabolic process]
GO:0006886 [intracellular protein transport]
GO:0007021 [tubulin complex assembly]
GO:0007049 [cell cycle]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0015031 [protein transport]
GO:0016328 [lateral plasma membrane]
GO:0019003 [GDP binding]
GO:0031113 [regulation of microtubule polymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0034260 [negative regulation of GTPase activity]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
GO:0051297 [centrosome organization]
GO:0051457 [maintenance of protein location in nucleus]
GO:0070062 [extracellular exosome]
GO:0070830 [bicellular tight junction assembly]
Show all
 184 aa
20.9 kDa 		No 0
ARL2-003
ENSP00000432971
ENST00000533729
P36404 [Direct mapping]
ADP-ribosylation factor-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006112 [energy reserve metabolic process]
GO:0006886 [intracellular protein transport]
GO:0007021 [tubulin complex assembly]
GO:0007049 [cell cycle]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016328 [lateral plasma membrane]
GO:0031113 [regulation of microtubule polymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0034260 [negative regulation of GTPase activity]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
GO:0051297 [centrosome organization]
GO:0051457 [maintenance of protein location in nucleus]
GO:0070062 [extracellular exosome]
GO:0070830 [bicellular tight junction assembly]
Show all
 157 aa
18.1 kDa 		No 0
ARL2-005
ENSP00000436021
ENST00000529384
P36404 [Direct mapping]
ADP-ribosylation factor-like protein 2
Q53YD8 [Target identity:100%; Query identity:100%]
ADP-ribosylation factor-like 2; ADP-ribosylation factor-like 2 variant; HCG23373, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006112 [energy reserve metabolic process]
GO:0006886 [intracellular protein transport]
GO:0007021 [tubulin complex assembly]
GO:0007049 [cell cycle]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0015031 [protein transport]
GO:0016328 [lateral plasma membrane]
GO:0031113 [regulation of microtubule polymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0034260 [negative regulation of GTPase activity]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
GO:0051297 [centrosome organization]
GO:0051457 [maintenance of protein location in nucleus]
GO:0070062 [extracellular exosome]
GO:0070830 [bicellular tight junction assembly]
Show all
 184 aa
20.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.