Expression of TMEM110 in cancer - Summary - The Human Protein Atlas

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TMEM110

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM110
Gene description	Transmembrane protein 110
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in gastrointestinal mucosa and CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA051855
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051855

GENE INFORMATION
Gene name	TMEM110 (HGNC Symbol)
Synonyms	MGC52022
Description	Transmembrane protein 110 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p21.1
Chromosome location (bp)	52836219 - 52897596
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213533 (version 83.38)
Entrez gene	375346
UniProt	Q86TL2 (UniProt - Evidence at protein level)
neXtProt	NX_Q86TL2
Antibodypedia	TMEM110 antibodies

PROTEIN BROWSER

TMEM110-004	TMEM110-007	TMEM110-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM110-004 ENSP00000347195 ENST00000355083	Q86TL2 [Direct mapping] Transmembrane protein 110 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005789 [endoplasmic reticulum membrane] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] Show all	294 aa 33.2 kDa	No	4
TMEM110-007 ENSP00000418967 ENST00000482155	H7C551 [Direct mapping] Transmembrane protein 110 Show all	Predicted intracellular proteins Show all		39 aa 4.5 kDa	No	0
TMEM110-008 ENSP00000418652 ENST00000485356	H7C503 [Direct mapping] Transmembrane protein 110 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	89 aa 10.1 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.