Expression of TMX2 in cancer - Summary - The Human Protein Atlas

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TMX2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMX2
Gene description	Thioredoxin-related transmembrane protein 2
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a majority of tissues, must abundant in glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA040282 , HPA063763
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), urothelial cancer (unfavourable), head and neck cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Head and neck cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040282	HPA063763

GENE INFORMATION
Gene name	TMX2 (HGNC Symbol)
Synonyms	PDIA12, TXNDC14
Description	Thioredoxin-related transmembrane protein 2 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q12.1
Chromosome location (bp)	57712600 - 57740973
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213593 (version 83.38)
Entrez gene	51075
UniProt	Q9Y320 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y320
Antibodypedia	TMX2 antibodies

PROTEIN BROWSER

TMX2-001	TMX2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMX2-001 ENSP00000367562 ENST00000378312	Q9Y320 [Direct mapping] Thioredoxin-related transmembrane protein 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005623 [cell] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0045454 [cell redox homeostasis] Show all	258 aa 29.6 kDa	Yes	0
TMX2-002 ENSP00000278422 ENST00000278422	Q9Y320 [Direct mapping] Thioredoxin-related transmembrane protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005623 [cell] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0045454 [cell redox homeostasis] Show all	296 aa 34 kDa	Yes	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.