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NDUFS3

GENERAL INFORMATION

Gene name

 NDUFS3

Gene description

 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA004484
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004484

GENE INFORMATION

Gene name

 NDUFS3 (HGNC Symbol)

Synonyms

 CI-30

Description

 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009]

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 47565336 - 47584562

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213619 (version 83.38)

Entrez gene

 4722

UniProt

 O75489 (UniProt - Evidence at protein level)

neXtProt

 NX_O75489

Antibodypedia

 NDUFS3 antibodies

PROTEIN BROWSER
NDUFS3-001
NDUFS3-002
NDUFS3-004
NDUFS3-005
NDUFS3-006
NDUFS3-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NDUFS3-001
ENSP00000263774
ENST00000263774
O75489 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SignalP predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003954 [NADH dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0005759 [mitochondrial matrix]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0009055 [electron carrier activity]
GO:0016651 [oxidoreductase activity, acting on NAD(P)H]
GO:0021762 [substantia nigra development]
GO:0022904 [respiratory electron transport chain]
GO:0030308 [negative regulation of cell growth]
GO:0031966 [mitochondrial membrane]
GO:0043209 [myelin sheath]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0072593 [reactive oxygen species metabolic process]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
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 264 aa
30.2 kDa 		No 0
NDUFS3-002
ENSP00000434970
ENST00000534716
O75489 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SignalP predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003954 [NADH dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0005759 [mitochondrial matrix]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0009055 [electron carrier activity]
GO:0021762 [substantia nigra development]
GO:0022904 [respiratory electron transport chain]
GO:0030308 [negative regulation of cell growth]
GO:0031966 [mitochondrial membrane]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0072593 [reactive oxygen species metabolic process]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
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 132 aa
14.7 kDa 		No 0
NDUFS3-004
ENSP00000433753
ENST00000529276
E9PJE7 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
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   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 67 aa
7.2 kDa 		No 0
NDUFS3-005
ENSP00000432099
ENST00000528192
E9PS48 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
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   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 161 aa
17.5 kDa 		No 0
NDUFS3-006
ENSP00000431588
ENST00000530295
E9PKL8 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
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   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 78 aa
8.6 kDa 		No 0
NDUFS3-012
ENSP00000433405
ENST00000534208
G3V194 [Direct mapping]
NADH dehydrogenase (Ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase), isoform CRA_c; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
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   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 121 aa
13.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.