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ATF6B

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GENERAL INFORMATION

Gene name

 ATF6B

Gene description

 Activating transcription factor 6 beta

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & nucleoli.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Nucleoli (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA046871
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & nucleoli.

Main location

 Nucleus (supported), Nucleoli (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA046871 HUVEC TERT2 Nucleus
Nucleoli
HPA046871 U-251 MG Nucleus
Nucleoli

GENE INFORMATION

Gene name

 ATF6B (HGNC Symbol)

Synonyms

 CREBL1, G13

Description

 Activating transcription factor 6 beta (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Chromosome

 6

Cytoband

Chromosome location (bp)

 32098176 - 32128253

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213676 (version 83.38)

Entrez gene

 1388

UniProt

 Q99941 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99941

Antibodypedia

 ATF6B antibodies

PROTEIN BROWSER
ATF6B-001
ATF6B-002
ATF6B-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATF6B-001
ENSP00000364347
ENST00000375201
Q99941 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-6 beta Processed cyclic AMP-dependent transcription factor ATF-6 beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032993 [protein-DNA complex]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
Show all
 700 aa
76.4 kDa 		No 1
ATF6B-002
ENSP00000364349
ENST00000375203
Q99941 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-6 beta Processed cyclic AMP-dependent transcription factor ATF-6 beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032993 [protein-DNA complex]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
Show all
 703 aa
76.7 kDa 		No 1
ATF6B-008
ENSP00000393419
ENST00000453203
H0Y7D7 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-6 beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 142 aa
16.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.