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S1PR3

GENERAL INFORMATION

Gene name

 S1PR3

Gene description

 Sphingosine-1-phosphate receptor 3

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22, ASC TERT1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), colorectal cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 S1PR3 (HGNC Symbol)

Synonyms

 EDG-3, EDG3

Description

 Sphingosine-1-phosphate receptor 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q22.1

Chromosome location (bp)

 88991447 - 89005010

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213694 (version 83.38)

Entrez gene

 1903

UniProt

 Q99500 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99500

Antibodypedia

 S1PR3 antibodies

PROTEIN BROWSER
S1PR3-001
S1PR3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
S1PR3-001
ENSP00000365006
ENST00000375846
Q99500 [Direct mapping]
Sphingosine 1-phosphate receptor 3
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Lysolipids receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0001816 [cytokine production]
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0004930 [G-protein coupled receptor activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007219 [Notch signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0016021 [integral component of membrane]
GO:0032651 [regulation of interleukin-1 beta production]
GO:0038036 [sphingosine-1-phosphate receptor activity]
GO:1903141 [negative regulation of establishment of endothelial barrier]
Show all
 378 aa
42.3 kDa 		No 7
S1PR3-002
ENSP00000350878
ENST00000358157
Q99500 [Direct mapping]
Sphingosine 1-phosphate receptor 3
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Lysolipids receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0004930 [G-protein coupled receptor activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008284 [positive regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0016021 [integral component of membrane]
GO:0038036 [sphingosine-1-phosphate receptor activity]
GO:1903141 [negative regulation of establishment of endothelial barrier]
Show all
 378 aa
42.3 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.