Expression of SLC35F6 in cancer - Summary - The Human Protein Atlas

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SLC35F6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC35F6
Gene description	Solute carrier family 35, member F6
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA034655
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034655

GENE INFORMATION
Gene name	SLC35F6 (HGNC Symbol)
Synonyms	ANT2BP, C2orf18, FLJ20555, TANGO9
Description	Solute carrier family 35, member F6 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	26764284 - 26781231
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213699 (version 83.38)
Entrez gene	54978
UniProt	Q8N357 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N357
Antibodypedia	SLC35F6 antibodies

PROTEIN BROWSER

SLC35F6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC35F6-001 ENSP00000345528 ENST00000344420	Q8N357 [Direct mapping] Solute carrier family 35 member F6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0008284 [positive regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] GO:1901029 [negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] Show all	371 aa 40.2 kDa	Yes	9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.