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CLIC1

GENERAL INFORMATION

Gene name

 CLIC1

Gene description

 Chloride intracellular channel 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most glandular epithelial cells, also membranous expression in renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
CAB020825 , CAB040557
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Stomach cancer

STAINING SUMMARY
CAB020825
CAB040557

GENE INFORMATION

Gene name

 CLIC1 (HGNC Symbol)

Synonyms

 NCC27, p64CLCP

Description

 Chloride intracellular channel 1 (HGNC Symbol)

Entrez gene summary

 Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31730581 - 31739763

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213719 (version 83.38)

Entrez gene

 1192

UniProt

 O00299 (UniProt - Evidence at protein level)

neXtProt

 NX_O00299

Antibodypedia

 CLIC1 antibodies

PROTEIN BROWSER
CLIC1-001
CLIC1-002
CLIC1-003
CLIC1-004
CLIC1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLIC1-001
ENSP00000364940
ENST00000375784
O00299 [Direct mapping]
Chloride intracellular channel protein 1
Q5SRT3 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006821 [chloride transport]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:1902476 [chloride transmembrane transport]
Show all
 241 aa
26.9 kDa 		No 0
CLIC1-002
ENSP00000364935
ENST00000375780
O00299 [Direct mapping]
Chloride intracellular channel protein 1
Q5SRT3 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006821 [chloride transport]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:1902476 [chloride transmembrane transport]
Show all
 241 aa
26.9 kDa 		No 0
CLIC1-003
ENSP00000379229
ENST00000395892
O00299 [Direct mapping]
Chloride intracellular channel protein 1
Q5SRT3 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006821 [chloride transport]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:1902476 [chloride transmembrane transport]
Show all
 241 aa
26.9 kDa 		No 0
CLIC1-004
ENSP00000364934
ENST00000375779
O00299 [Direct mapping]
Chloride intracellular channel protein 1
Q5SRT3 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006821 [chloride transport]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:1902476 [chloride transmembrane transport]
Show all
 241 aa
26.9 kDa 		No 0
CLIC1-202
ENSP00000479808
ENST00000616760
O00299 [Direct mapping]
Chloride intracellular channel protein 1
Q5SRT3 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006821 [chloride transport]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:1902476 [chloride transmembrane transport]
Show all
 241 aa
26.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.