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GTF2H4

GENERAL INFORMATION

Gene name

 GTF2H4

Gene description

 General transcription factor IIH, polypeptide 4, 52kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 GTF2H4 (HGNC Symbol)

Synonyms

 P52, TFB2, TFIIH

Description

 General transcription factor IIH, polypeptide 4, 52kDa (HGNC Symbol)

Entrez gene summary

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 30908184 - 30914106

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213780 (version 83.38)

Entrez gene

 2968

UniProt

 Q92759 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q92759

Antibodypedia

 GTF2H4 antibodies

PROTEIN BROWSER
GTF2H4-001
GTF2H4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GTF2H4-001
ENSP00000259895
ENST00000259895
Q92759 [Direct mapping]
General transcription factor IIH subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005675 [holo TFIIH complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032508 [DNA duplex unwinding]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0050434 [positive regulation of viral transcription]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 462 aa
52.2 kDa 		No 0
GTF2H4-002
ENSP00000365493
ENST00000376316
Q92759 [Direct mapping]
General transcription factor IIH subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005675 [holo TFIIH complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032508 [DNA duplex unwinding]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0050434 [positive regulation of viral transcription]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 462 aa
52.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.