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Killer cell lectin-like receptor subfamily K, member 1 (HGNC Symbol)
Entrez gene summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
P26718 [Direct mapping] NKG2-D type II integral membrane protein A0A024RAP8 [Target identity:100%; Query identity:100%] HCG2009644, isoform CRA_b; Protein KLRC4-KLRK1
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CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
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GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002860 [positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0019900 [kinase binding] GO:0030101 [natural killer cell activation] GO:0030154 [cell differentiation] GO:0030246 [carbohydrate binding] GO:0030887 [positive regulation of myeloid dendritic cell activation] GO:0031295 [T cell costimulation] GO:0032394 [MHC class Ib receptor activity] GO:0032729 [positive regulation of interferon-gamma production] GO:0034260 [negative regulation of GTPase activity] GO:0042288 [MHC class I protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0045087 [innate immune response] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0050776 [regulation of immune response] GO:0050830 [defense response to Gram-positive bacterium] GO:0071222 [cellular response to lipopolysaccharide] GO:2000502 [negative regulation of natural killer cell chemotaxis]
P26718 [Direct mapping] NKG2-D type II integral membrane protein A0A024RAP8 [Target identity:100%; Query identity:100%] HCG2009644, isoform CRA_b; Protein KLRC4-KLRK1
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CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)