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KCTD11

GENERAL INFORMATION

Gene name

 KCTD11

Gene description

 Potassium channel tetramerization domain containing 11

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression i most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA052035
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable) and endometrial cancer (favourable).
Ovarian cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA052035

GENE INFORMATION

Gene name

 KCTD11 (HGNC Symbol)

Synonyms

 C17orf36, KCASH1, REN

Description

 Potassium channel tetramerization domain containing 11 (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7351889 - 7354944

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213859 (version 83.38)

Entrez gene

 147040

UniProt

 Q693B1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q693B1

Antibodypedia

 KCTD11 antibodies

PROTEIN BROWSER
KCTD11-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCTD11-001
ENSP00000328352
ENST00000333751
Q693B1 [Direct mapping]
BTB/POZ domain-containing protein KCTD11
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Predicted intracellular proteins
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GO:0005737 [cytoplasm]
GO:0007049 [cell cycle]
GO:0007399 [nervous system development]
GO:0007406 [negative regulation of neuroblast proliferation]
GO:0016567 [protein ubiquitination]
GO:0030154 [cell differentiation]
GO:0040008 [regulation of growth]
GO:0042127 [regulation of cell proliferation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0051260 [protein homooligomerization]
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 232 aa
25.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.