Tissue expression of LTB4R - Summary - The Human Protein Atlas

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LTB4R

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	LTB4R
Gene description	Leukotriene B4 receptor
Protein class	G-protein coupled receptors Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (skin)
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (lymph node, spleen)

Protein evidence

Evidence at protein level

Protein expression

Membranous and cytoplasmic expression in immune cells in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA003873
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lymph node, spleen)

GENE INFORMATION
Gene name	LTB4R (HGNC Symbol)
Synonyms	BLTR, CMKRL1, GPR16, LTB4R1, P2RY7, P2Y7
Description	Leukotriene B4 receptor (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q12
Chromosome location (bp)	24311450 - 24318036
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213903 (version 83.38)
Entrez gene	1241
UniProt	Q15722 (UniProt - Evidence at protein level)
neXtProt	NX_Q15722
Antibodypedia	LTB4R antibodies

PROTEIN BROWSER

LTB4R-001	LTB4R-002	LTB4R-003	LTB4R-004	LTB4R-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LTB4R-001 ENSP00000307445 ENST00000345363	Q15722 [Direct mapping] Leukotriene B4 receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0001632 [leukotriene B4 receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0006936 [muscle contraction] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008528 [G-protein coupled peptide receptor activity] GO:0016021 [integral component of membrane] GO:0061737 [leukotriene signaling pathway] Show all	352 aa 37.6 kDa	No	7
LTB4R-002 ENSP00000380008 ENST00000396789	Q15722 [Direct mapping] Leukotriene B4 receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0001632 [leukotriene B4 receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0006936 [muscle contraction] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008528 [G-protein coupled peptide receptor activity] GO:0016021 [integral component of membrane] GO:0045121 [membrane raft] GO:0061737 [leukotriene signaling pathway] Show all	352 aa 37.6 kDa	No	7
LTB4R-003 ENSP00000380002 ENST00000396782	Q15722 [Direct mapping] Leukotriene B4 receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0001632 [leukotriene B4 receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0006936 [muscle contraction] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008528 [G-protein coupled peptide receptor activity] GO:0016021 [integral component of membrane] GO:0061737 [leukotriene signaling pathway] Show all	352 aa 37.6 kDa	No	7
LTB4R-004 ENSP00000450457 ENST00000553481	G3V244 [Direct mapping] Leukotriene B4 receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0061737 [leukotriene signaling pathway] Show all	102 aa 10.9 kDa	No	2
LTB4R-005 ENSP00000451929 ENST00000556141	G3V4Q5 [Direct mapping] Leukotriene B4 receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0061737 [leukotriene signaling pathway] Show all	232 aa 24.9 kDa	No	3

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The Human Protein Atlas

The Human Protein Atlas project is funded
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