Expression of LTB4R2 in cancer - Summary - The Human Protein Atlas

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LTB4R2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LTB4R2
Gene description	Leukotriene B4 receptor 2
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HaCaT)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA029680 , CAB022689
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA029680	CAB022689

GENE INFORMATION
Gene name	LTB4R2 (HGNC Symbol)
Synonyms	BLT2, BLTR2, JULF2, NOP9
Description	Leukotriene B4 receptor 2 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q12
Chromosome location (bp)	24305734 - 24312053
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213906 (version 83.38)
Entrez gene	56413
UniProt	Q9NPC1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NPC1
Antibodypedia	LTB4R2 antibodies

PROTEIN BROWSER

LTB4R2-001	LTB4R2-002	LTB4R2-003	LTB4R2-004	LTB4R2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LTB4R2-001 ENSP00000432146 ENST00000528054	Q9NPC1 [Direct mapping] Leukotriene B4 receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001632 [leukotriene B4 receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008528 [G-protein coupled peptide receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0061737 [leukotriene signaling pathway] Show all	389 aa 41.5 kDa	No	7
LTB4R2-002 ENSP00000433290 ENST00000533293	Q9NPC1 [Direct mapping] Leukotriene B4 receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001632 [leukotriene B4 receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008528 [G-protein coupled peptide receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0061737 [leukotriene signaling pathway] Show all	358 aa 37.9 kDa	No	7
LTB4R2-003 ENSP00000434760 ENST00000530080	E9PNJ6 [Direct mapping] Leukotriene B4 receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0061737 [leukotriene signaling pathway] Show all	319 aa 33.8 kDa	No	7
LTB4R2-004 ENSP00000436668 ENST00000527924	E9PIC1 [Direct mapping] Leukotriene B4 receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0061737 [leukotriene signaling pathway] Show all	160 aa 17.2 kDa	No	4
LTB4R2-201 ENSP00000445772 ENST00000543919	Q9NPC1 [Direct mapping] Leukotriene B4 receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001632 [leukotriene B4 receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008528 [G-protein coupled peptide receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0051546 [keratinocyte migration] GO:0061737 [leukotriene signaling pathway] Show all	358 aa 37.9 kDa	No	7

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