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CSNK1E

GENERAL INFORMATION

Gene name

 CSNK1E

Gene description

 Casein kinase 1, epsilon

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA026288 , CAB009626
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Stomach cancer

STAINING SUMMARY
HPA026288
CAB009626

GENE INFORMATION

Gene name

 CSNK1E (HGNC Symbol)

Synonyms

 CKIE, CKIepsilon, HCKIE

Description

 Casein kinase 1, epsilon (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 38290691 - 38398522

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213923 (version 83.38)

Entrez gene

 1454

UniProt

 P49674 (UniProt - Evidence at protein level)

neXtProt

 NX_P49674

Antibodypedia

 CSNK1E antibodies

PROTEIN BROWSER
CSNK1E-001
CSNK1E-002
CSNK1E-003
CSNK1E-004
CSNK1E-005
CSNK1E-006
CSNK1E-008
CSNK1E-009
CSNK1E-016
CSNK1E-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSNK1E-001
ENSP00000383067
ENST00000400206
P49674 [Direct mapping]
Casein kinase I isoform epsilon
Q5U045 [Target identity:100%; Query identity:100%]
Casein kinase 1 epsilon; Casein kinase 1, epsilon; HCG2014051, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0006996 [organelle organization]
GO:0007165 [signal transduction]
GO:0007623 [circadian rhythm]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032922 [circadian regulation of gene expression]
GO:0042752 [regulation of circadian rhythm]
GO:0044822 [poly(A) RNA binding]
Show all
 416 aa
47.3 kDa 		No 0
CSNK1E-002
ENSP00000384074
ENST00000403904
P49674 [Direct mapping]
Casein kinase I isoform epsilon
Q5U045 [Target identity:100%; Query identity:100%]
Casein kinase 1 epsilon; Casein kinase 1, epsilon; HCG2014051, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0006996 [organelle organization]
GO:0007165 [signal transduction]
GO:0007623 [circadian rhythm]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032922 [circadian regulation of gene expression]
GO:0042752 [regulation of circadian rhythm]
GO:0044822 [poly(A) RNA binding]
Show all
 416 aa
47.3 kDa 		No 0
CSNK1E-003
ENSP00000352929
ENST00000359867
P49674 [Direct mapping]
Casein kinase I isoform epsilon
Q5U045 [Target identity:100%; Query identity:100%]
Casein kinase 1 epsilon; Casein kinase 1, epsilon; HCG2014051, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0006996 [organelle organization]
GO:0007165 [signal transduction]
GO:0007623 [circadian rhythm]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032922 [circadian regulation of gene expression]
GO:0042752 [regulation of circadian rhythm]
GO:0044822 [poly(A) RNA binding]
Show all
 416 aa
47.3 kDa 		No 0
CSNK1E-004
ENSP00000407235
ENST00000413574
B0QY34 [Direct mapping]
Casein kinase I isoform epsilon
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 336 aa
38.4 kDa 		No 0
CSNK1E-005
ENSP00000384426
ENST00000405675
B0QY35 [Direct mapping]
Casein kinase I isoform epsilon
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 311 aa
36.1 kDa 		No 0
CSNK1E-006
ENSP00000400494
ENST00000366216
H0Y5S9 [Direct mapping]
Casein kinase I isoform epsilon
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 119 aa
12.9 kDa 		No 0
CSNK1E-008
ENSP00000412335
ENST00000430335
B0QY36 [Direct mapping]
Casein kinase I isoform epsilon
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 225 aa
25.6 kDa 		No 0
CSNK1E-009
ENSP00000403057
ENST00000451964
H0Y645 [Direct mapping]
Casein kinase I isoform epsilon
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 270 aa
31.2 kDa 		No 0
CSNK1E-016
ENSP00000403610
ENST00000431632
H0Y682 [Direct mapping]
Casein kinase I isoform epsilon
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 144 aa
15.9 kDa 		No 0
CSNK1E-201
ENSP00000380044
ENST00000396832
P49674 [Direct mapping]
Casein kinase I isoform epsilon
Q5U045 [Target identity:100%; Query identity:100%]
Casein kinase 1 epsilon; Casein kinase 1, epsilon; HCG2014051, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0006996 [organelle organization]
GO:0007165 [signal transduction]
GO:0007623 [circadian rhythm]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030529 [ribonucleoprotein complex]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032922 [circadian regulation of gene expression]
GO:0034613 [cellular protein localization]
GO:0042752 [regulation of circadian rhythm]
GO:0044822 [poly(A) RNA binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 416 aa
47.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.