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HBE1

GENERAL INFORMATION

Gene name

 HBE1

Gene description

 Hemoglobin, epsilon 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (K-562)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in erythrocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
HPA043234
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA043234

GENE INFORMATION

Gene name

 HBE1 (HGNC Symbol)

Synonyms

 HBE

Description

 Hemoglobin, epsilon 1 (HGNC Symbol)

Entrez gene summary

 The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3' [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 5268345 - 5505617

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213931 (version 83.38)

Entrez gene

 3046

UniProt

 P02100 (UniProt - Evidence at protein level)

neXtProt

 NX_P02100

Antibodypedia

 HBE1 antibodies

PROTEIN BROWSER
HBE1-001
HBE1-002
HBE1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HBE1-001
ENSP00000369586
ENST00000380237
P02100 [Direct mapping]
Hemoglobin subunit epsilon
D9YZU7 [Target identity:100%; Query identity:100%]
Hemoglobin, epsilon 1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005829 [cytosol]
GO:0005833 [hemoglobin complex]
GO:0007596 [blood coagulation]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0031721 [hemoglobin alpha binding]
GO:0051291 [protein heterooligomerization]
GO:0072562 [blood microparticle]
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 147 aa
16.2 kDa 		No 0
HBE1-002
ENSP00000380104
ENST00000396895
A8MUF7 [Direct mapping]
Hemoglobin subunit epsilon
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005833 [hemoglobin complex]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
Show all
 87 aa
9.5 kDa 		No 0
HBE1-201
ENSP00000292896
ENST00000292896
P02100 [Direct mapping]
Hemoglobin subunit epsilon
D9YZU7 [Target identity:100%; Query identity:100%]
Hemoglobin, epsilon 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005829 [cytosol]
GO:0007596 [blood coagulation]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0072562 [blood microparticle]
Show all
 147 aa
16.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.