Expression of HBG1 in cancer - Summary - The Human Protein Atlas

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HBG1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HBG1
Gene description	Hemoglobin, gamma A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (K-562)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in erythrocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images. Tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA043234
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043234

GENE INFORMATION
Gene name	HBG1 (HGNC Symbol)
Synonyms	HBG-T2
Description	Hemoglobin, gamma A (HGNC Symbol)
Entrez gene summary	The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	5248083 - 5249892
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213934 (version 83.38)
Entrez gene	3047
UniProt	P69891 (UniProt - Evidence at protein level)
neXtProt	NX_P69891
Antibodypedia	HBG1 antibodies

PROTEIN BROWSER

HBG1-001	HBG1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HBG1-001 ENSP00000327431 ENST00000330597	P69891 [Direct mapping] Hemoglobin subunit gamma-1 D9YZU8 [Target identity:100%; Query identity:100%] Hemoglobin, gamma A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005344 [oxygen transporter activity] GO:0005506 [iron ion binding] GO:0005829 [cytosol] GO:0005833 [hemoglobin complex] GO:0007596 [blood coagulation] GO:0015671 [oxygen transport] GO:0019825 [oxygen binding] GO:0020037 [heme binding] Show all	147 aa 16.1 kDa	No	0
HBG1-002 ENSP00000488759 ENST00000632727		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		30 aa 3.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.