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CLDN9

GENERAL INFORMATION

Gene name

 CLDN9

Gene description

 Claudin 9

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (CAPAN-2, MCF7, SCLC-21H)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and stomach cancer (unfavourable).
Endometrial cancer p<0.001
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CLDN9

Synonyms

Description

 Claudin 9 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein is one of the entry cofactors for hepatitis C virus. Mouse studies revealed that this gene is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Jun 2010]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 3012456 - 3014505

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213937 (version 83.38)

Entrez gene

 9080

UniProt

 O95484 (UniProt - Evidence at protein level)

neXtProt

 NX_O95484

Antibodypedia

 CLDN9 antibodies

PROTEIN BROWSER
CLDN9-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLDN9-001
ENSP00000398017
ENST00000445369
O95484 [Direct mapping]
Claudin-9
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
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GO:0005198 [structural molecule activity]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules]
GO:0034329 [cell junction assembly]
GO:0042802 [identical protein binding]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
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 217 aa
22.8 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.