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Most of the cancer tissues displayed weak to moderate cytoplasmic positivity. Several cases of pancreatic cancer showed strong positivity. Lymphomas, prostate and testicular cancers were mainly negative.
GENE INFORMATION
Gene name
ITGA1 (HGNC Symbol)
Synonyms
CD49a, VLA1
Description
Integrin, alpha 1 (HGNC Symbol)
Entrez gene summary
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]