Expression of CARKD in cancer - Summary - The Human Protein Atlas

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CARKD

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CARKD
Gene description	Carbohydrate kinase domain containing
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA010551
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010551

GENE INFORMATION
Gene name	CARKD (HGNC Symbol)
Synonyms	FLJ10769, LP3298
Description	Carbohydrate kinase domain containing (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q34
Chromosome location (bp)	110615460 - 110639993
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213995 (version 83.38)
Entrez gene	55739
UniProt	Q8IW45 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IW45
Antibodypedia	CARKD antibodies

PROTEIN BROWSER

CARKD-001	CARKD-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CARKD-001 ENSP00000311984 ENST00000309957	Q8IW45 [Direct mapping] ATP-dependent (S)-NAD(P)H-hydrate dehydratase A0A024RDX4 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Enzymes ENZYME proteins Lyases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0047453 [ATP-dependent NAD(P)H-hydrate dehydratase activity] GO:0052855 [ADP-dependent NAD(P)H-hydrate dehydratase activity] Show all	390 aa 41.4 kDa	Yes	0
CARKD-201 ENSP00000413191 ENST00000424185	Q8IW45 [Direct mapping] ATP-dependent (S)-NAD(P)H-hydrate dehydratase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005739 [mitochondrion] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0047453 [ATP-dependent NAD(P)H-hydrate dehydratase activity] GO:0052855 [ADP-dependent NAD(P)H-hydrate dehydratase activity] Show all	237 aa 25.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.