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REPIN1

GENERAL INFORMATION

Gene name

 REPIN1

Gene description

 Replication initiator 1

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and nucleolar expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA036022
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), stomach cancer (favourable), renal cancer (favourable) and urothelial cancer (favourable).
Pancreatic cancer p<0.001
Stomach cancer p<0.001
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036022

GENE INFORMATION

Gene name

 REPIN1 (HGNC Symbol)

Synonyms

 AP4, H_DJ0584D14.12, RIP60, Zfp464, ZNF464

Description

 Replication initiator 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 q36.1

Chromosome location (bp)

 150368189 - 150374044

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000214022 (version 83.38)

Entrez gene

 29803

UniProt

 Q9BWE0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BWE0

Antibodypedia

 REPIN1 antibodies

PROTEIN BROWSER
«
REPIN1-001
REPIN1-002
REPIN1-004
REPIN1-006
REPIN1-011
REPIN1-012
REPIN1-014
REPIN1-016
REPIN1-018
REPIN1-201
REPIN1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
REPIN1-001
ENSP00000420578
ENST00000479668
C9J590 [Direct mapping]
Replication initiator 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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 136 aa
15.3 kDa 		Yes 0
REPIN1-002
ENSP00000417291
ENST00000489432
Q9BWE0 [Direct mapping]
Replication initiator 1
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0022626 [cytosolic ribosome]
GO:0031965 [nuclear membrane]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:2000191 [regulation of fatty acid transport]
GO:2001273 [regulation of glucose import in response to insulin stimulus]
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 624 aa
69.9 kDa 		No 0
REPIN1-004
ENSP00000418507
ENST00000466559
C9J0L4 [Direct mapping]
Replication initiator 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 55 aa
6.1 kDa 		No 0
REPIN1-006
ENSP00000417982
ENST00000482680
C9J590 [Direct mapping]
Replication initiator 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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 136 aa
15.3 kDa 		Yes 0
REPIN1-011
ENSP00000419789
ENST00000475514
C9JZE3 [Direct mapping]
Replication initiator 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0046872 [metal ion binding]
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 366 aa
41.4 kDa 		No 0
REPIN1-012
ENSP00000419872
ENST00000488943
C9JYJ8 [Direct mapping]
Replication initiator 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0046872 [metal ion binding]
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 394 aa
44.1 kDa 		No 0
REPIN1-014
ENSP00000428562
ENST00000519397
E7EVL6 [Direct mapping]
Replication initiator 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0046872 [metal ion binding]
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 146 aa
16.1 kDa 		No 0
REPIN1-016
ENSP00000428129
ENST00000518514
E5RK52 [Direct mapping]
Replication initiator 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 136 aa
13.6 kDa 		No 0
REPIN1-018
ENSP00000388287
ENST00000425389
Q9BWE0 [Direct mapping]
Replication initiator 1
A0A090N8H1 [Target identity:100%; Query identity:100%]
HCG1990708, isoform CRA_c; Replication initiator 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0006260 [DNA replication]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
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 567 aa
63.6 kDa 		No 0
REPIN1-201
ENSP00000380451
ENST00000397281
Q9BWE0 [Direct mapping]
Replication initiator 1
A0A090N8H1 [Target identity:100%; Query identity:100%]
HCG1990708, isoform CRA_c; Replication initiator 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0006260 [DNA replication]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
Show all
 567 aa
63.6 kDa 		No 0
REPIN1-202
ENSP00000407714
ENST00000444957
Q9BWE0 [Direct mapping]
Replication initiator 1
A0A090N8H1 [Target identity:100%; Query identity:100%]
HCG1990708, isoform CRA_c; Replication initiator 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0006260 [DNA replication]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
Show all
 567 aa
63.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.