Expression of CPNE1 in cancer - Summary

GENERAL INFORMATION
Gene name	CPNE1
Gene description	Copine I
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	18
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA072634
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA072634

GENE INFORMATION
Gene name	CPNE1 (HGNC Symbol)
Synonyms	CPN1
Description	Copine I (HGNC Symbol)
Entrez gene summary	Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008]
Chromosome	20
Cytoband	q11.22
Chromosome location (bp)	35626031 - 35664956
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000214078 (version 83.38)
Entrez gene	8904
UniProt	Q99829 (UniProt - Evidence at protein level)
neXtProt	NX_Q99829
Antibodypedia	CPNE1 antibodies

PROTEIN BROWSER

CPNE1-004	CPNE1-005	CPNE1-007	CPNE1-008	CPNE1-009	CPNE1-010	CPNE1-011	CPNE1-012	CPNE1-013	CPNE1-014	CPNE1-015	CPNE1-016	CPNE1-017	CPNE1-020	CPNE1-021	CPNE1-032	CPNE1-033	CPNE1-034

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPNE1-004 ENSP00000336945 ENST00000352393	Q99829 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0004175 [endopeptidase activity] GO:0005215 [transporter activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006508 [proteolysis] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0042803 [protein homodimerization activity] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043392 [negative regulation of DNA binding] GO:0044281 [small molecule metabolic process] GO:0045666 [positive regulation of neuron differentiation] GO:0046474 [glycerophospholipid biosynthetic process] GO:0051059 [NF-kappaB binding] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070062 [extracellular exosome] GO:0071277 [cellular response to calcium ion] GO:1901223 [negative regulation of NIK/NF-kappaB signaling] GO:1903265 [positive regulation of tumor necrosis factor-mediated signaling pathway] GO:1990138 [neuron projection extension] Show all	537 aa 59.1 kDa	No	0
CPNE1-005 ENSP00000317257 ENST00000317677	B0QZ18 [Direct mapping] Copine-1; HCG38213, isoform CRA_b Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	542 aa 59.7 kDa	No	0
CPNE1-007 ENSP00000404355 ENST00000414664	Q5JX44 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	304 aa 33.9 kDa	No	0
CPNE1-008 ENSP00000401915 ENST00000420363	Q5JX59 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	209 aa 23.4 kDa	No	0
CPNE1-009 ENSP00000387434 ENST00000439806	Q5JX60 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	231 aa 25.8 kDa	No	0
CPNE1-010 ENSP00000391483 ENST00000437100	Q5JX55 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	152 aa 16.8 kDa	No	0
CPNE1-011 ENSP00000409955 ENST00000414711	Q5JX54 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	136 aa 14.9 kDa	No	0
CPNE1-012 ENSP00000397638 ENST00000440240	Q5JX56 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	174 aa 19.4 kDa	No	0
CPNE1-013 ENSP00000390626 ENST00000430570	Q5JX45 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	386 aa 42.7 kDa	No	0
CPNE1-014 ENSP00000416962 ENST00000412056	Q5JX52 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	305 aa 33.9 kDa	No	0
CPNE1-015 ENSP00000396069 ENST00000415920	H0Y524 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		208 aa 21.3 kDa	No	0
CPNE1-016 ENSP00000409794 ENST00000434795	Q5JX58 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	202 aa 22.7 kDa	No	0
CPNE1-017 ENSP00000389662 ENST00000416778	Q5JX61 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	213 aa 23.6 kDa	No	0
CPNE1-020 ENSP00000390141 ENST00000458038	Q5JX57 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	138 aa 15.2 kDa	No	0
CPNE1-021 ENSP00000412806 ENST00000435747	Q5JX53 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	67 aa 7.4 kDa	No	0
CPNE1-032 ENSP00000380584 ENST00000397442	A6PVH9 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	481 aa 53 kDa	No	0
CPNE1-033 ENSP00000415597 ENST00000437340	F2Z2V0 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	533 aa 58.6 kDa	No	0
CPNE1-034 ENSP00000380585 ENST00000397443	Q99829 [Direct mapping] Copine-1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0004175 [endopeptidase activity] GO:0005215 [transporter activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006508 [proteolysis] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0042803 [protein homodimerization activity] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043392 [negative regulation of DNA binding] GO:0044281 [small molecule metabolic process] GO:0045666 [positive regulation of neuron differentiation] GO:0046474 [glycerophospholipid biosynthetic process] GO:0051059 [NF-kappaB binding] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070062 [extracellular exosome] GO:0071277 [cellular response to calcium ion] GO:1901223 [negative regulation of NIK/NF-kappaB signaling] GO:1903265 [positive regulation of tumor necrosis factor-mediated signaling pathway] GO:1990138 [neuron projection extension] Show all	537 aa 59.1 kDa	No	0