Expression of LYRM4 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

LYRM4

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LYRM4
Gene description	LYR motif containing 4
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA030362
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030362

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most malignancies showed weak to moderate cytoplasmic staining. A few cases of colorectal, thyroid, gastric and pancreatic cancers displayed strong cytoplasmic immunoreactivity. Several cases of endometrial, cervical and skin cancers were negative.

GENE INFORMATION
Gene name	LYRM4 (HGNC Symbol)
Synonyms	C6orf149, CGI-203, ISD11
Description	LYR motif containing 4 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p25.1
Chromosome location (bp)	5102593 - 5260939
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000214113 (version 83.38)
Entrez gene	57128
UniProt	Q9HD34 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HD34
Antibodypedia	LYRM4 antibodies

PROTEIN BROWSER

LYRM4-001	LYRM4-004	LYRM4-005	LYRM4-006	LYRM4-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LYRM4-001 ENSP00000418787 ENST00000330636	Q9HD34 [Direct mapping] LYR motif-containing protein 4 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005759 [mitochondrial matrix] GO:0044281 [small molecule metabolic process] Show all	91 aa 10.8 kDa	No	0
LYRM4-004 ENSP00000418321 ENST00000468929	C9J799 [Direct mapping] LYR motif-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.6 kDa	No	0
LYRM4-005 ENSP00000419928 ENST00000480566	C9JY28 [Direct mapping] LYR motif-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 8.2 kDa	No	0
LYRM4-006 ENSP00000420026 ENST00000464010	C9JRX8 [Direct mapping] LYR motif-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		96 aa 11 kDa	No	0
LYRM4-009 ENSP00000443900 ENST00000500576	F5H189 [Direct mapping] LYR motif-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	130 aa 15.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.