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GNAT3

GENERAL INFORMATION

Gene name

 GNAT3

Gene description

 Guanine nucleotide binding protein, alpha transducing 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (breast cancer, urothelial cancer)
HPA (cell line):Cell line enriched (SCLC-21H)
HPA (normal tissue):Tissue enhanced (duodenum, small intestine)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (breast cancer, urothelial cancer)
0.050100150200250300350FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 GNAT3 (HGNC Symbol)

Synonyms

 GDCA, gustducin

Description

 Guanine nucleotide binding protein, alpha transducing 3 (HGNC Symbol)

Entrez gene summary

 Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome. [provided by RefSeq, Dec 2015]

Chromosome

 7

Cytoband

 q21.11

Chromosome location (bp)

 80458671 - 80512020

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000214415 (version 83.38)

Entrez gene

 346562

UniProt

 A8MTJ3 (UniProt - Evidence at transcript level)

neXtProt

 NX_A8MTJ3

Antibodypedia

 GNAT3 antibodies

PROTEIN BROWSER
GNAT3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNAT3-001
ENSP00000381339
ENST00000398291
A8MTJ3 [Direct mapping]
Guanine nucleotide-binding protein G(t) subunit alpha-3
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste]
GO:0001664 [G-protein coupled receptor binding]
GO:0001669 [acrosomal vesicle]
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0005930 [axoneme]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0016324 [apical plasma membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0030168 [platelet activation]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0035094 [response to nicotine]
GO:0043234 [protein complex]
GO:0046872 [metal ion binding]
GO:0050909 [sensory perception of taste]
GO:0050913 [sensory perception of bitter taste]
GO:0050916 [sensory perception of sweet taste]
GO:0050917 [sensory perception of umami taste]
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 354 aa
40.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.