Expression of SPINK13 in cancer - Summary

GENERAL INFORMATION
Gene name	SPINK13
Gene description	Serine peptidase inhibitor, Kazal type 13 (putative)
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (cervical cancer, lung cancer, renal cancer)
HPA (cell line):	Cell line enriched (HeLa)
HPA (normal tissue):	Tissue enriched (epididymis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Nuclear membrane and cytoplasmic expression in the brain, male reproductive tissues and endometrial glands.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA036456
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (cervical cancer, lung cancer, renal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA036456

GENE INFORMATION
Gene name	SPINK13 (HGNC Symbol)
Synonyms	HBVDNAPTP1, HESPINTOR, LiESP6, MGC149260, SPINK5L3
Description	Serine peptidase inhibitor, Kazal type 13 (putative) (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q32
Chromosome location (bp)	148268180 - 148286254
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000214510 (version 83.38)
Entrez gene	153218
UniProt	Q1W4C9 (UniProt - Inferred from homology)
neXtProt	NX_Q1W4C9
Antibodypedia	SPINK13 antibodies

PROTEIN BROWSER

SPINK13-001	SPINK13-002	SPINK13-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPINK13-001 ENSP00000421048 ENST00000512953	Q1W4C9 [Direct mapping] Serine protease inhibitor Kazal-type 13 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:1902225 [negative regulation of acrosome reaction] Show all	94 aa 11.1 kDa	Yes	0
SPINK13-002 ENSP00000426279 ENST00000511106	Q1W4C9 [Direct mapping] Serine protease inhibitor Kazal-type 13 Show all	Predicted intracellular proteins Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:1902225 [negative regulation of acrosome reaction] Show all	54 aa 6.4 kDa	No	0
SPINK13-201 ENSP00000381468 ENST00000398450	Q1W4C9 [Direct mapping] Serine protease inhibitor Kazal-type 13 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:1902225 [negative regulation of acrosome reaction] Show all	94 aa 11.1 kDa	Yes	0