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ARHGEF28

GENERAL INFORMATION

Gene name

 ARHGEF28

Gene description

 Rho guanine nucleotide exchange factor (GEF) 28

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with a granular patter.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA037602
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)

GENE INFORMATION

Gene name

 ARHGEF28 (HGNC Symbol)

Synonyms

 p190RhoGEF, RGNEF, RIP2

Description

 Rho guanine nucleotide exchange factor (GEF) 28 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Chromosome

 5

Cytoband

 q13.2

Chromosome location (bp)

 73626158 - 73941993

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000214944 (version 83.38)

Entrez gene

 64283

UniProt

 Q8N1W1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N1W1

Antibodypedia

 ARHGEF28 antibodies

PROTEIN BROWSER
ARHGEF28-001
ARHGEF28-004
ARHGEF28-005
ARHGEF28-006
ARHGEF28-007
ARHGEF28-009
ARHGEF28-201
ARHGEF28-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF28-001
ENSP00000296794
ENST00000296794
Q8N1W1 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 1651 aa
185.8 kDa 		No 0
ARHGEF28-004
ENSP00000412175
ENST00000426542
Q8N1W1 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 1705 aa
191.9 kDa 		No 0
ARHGEF28-005
ENSP00000411459
ENST00000437974
Q8N1W1 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 1731 aa
194.5 kDa 		No 0
ARHGEF28-006
ENSP00000421081
ENST00000512883
D6RGZ3 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 651 aa
73.9 kDa 		No 0
ARHGEF28-007
ENSP00000296799
ENST00000296799
Q8N1W1 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 1392 aa
157.3 kDa 		No 0
ARHGEF28-009
ENSP00000421859
ENST00000509848
D6RAP0 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 83 aa
9.4 kDa 		No 0
ARHGEF28-201
ENSP00000441436
ENST00000513042
Q8N1W1 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 1705 aa
191.9 kDa 		No 0
ARHGEF28-202
ENSP00000441913
ENST00000545377
Q8N1W1 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0021955 [central nervous system neuron axonogenesis]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0060052 [neurofilament cytoskeleton organization]
Show all
 1731 aa
194.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.