Expression of ISPD in cancer - Summary - The Human Protein Atlas

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ISPD

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ISPD
Gene description	Isoprenoid synthase domain containing
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and/or nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043810
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043810

GENE INFORMATION
Gene name	ISPD (HGNC Symbol)
Synonyms	hCG_1745121, IspD, Nip
Description	Isoprenoid synthase domain containing (HGNC Symbol)
Entrez gene summary	This gene encodes a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein. Mutations in this gene are the cause of Walker-Warburg syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Chromosome	7
Cytoband	p21.2
Chromosome location (bp)	16087527 - 16421322
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000214960 (version 83.38)
Entrez gene	729920
UniProt	A4D126 (UniProt - Evidence at protein level)
neXtProt	NX_A4D126
Antibodypedia	ISPD antibodies

PROTEIN BROWSER

ISPD-001	ISPD-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ISPD-001 ENSP00000385478 ENST00000407010	A4D126 [Direct mapping] Isoprenoid synthase domain-containing protein Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003824 [catalytic activity] GO:0006486 [protein glycosylation] GO:0007411 [axon guidance] GO:0008299 [isoprenoid biosynthetic process] GO:0035269 [protein O-linked mannosylation] GO:0050518 [2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity] Show all	451 aa 49.9 kDa	No	0
ISPD-003 ENSP00000382249 ENST00000399310	A4D126 [Direct mapping] Isoprenoid synthase domain-containing protein Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008299 [isoprenoid biosynthetic process] GO:0035269 [protein O-linked mannosylation] GO:0050518 [2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity] Show all	401 aa 44.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.