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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PHB2
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PHB2

Gene description

Prohibitin 2

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA039874 , CAB014889 , CAB026335
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA039874
CAB014889
CAB026335

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues displayed strong cytoplasmic staining with a granular pattern.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues displayed moderate to strong cytoplasmic staining with a granular pattern.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong cytoplasmic immunoreactivity with granular pattern was observed in cancer tissues.

GENE INFORMATION

Gene name

PHB2 (HGNC Symbol)

Synonyms

Bap37, BCAP37, p22, REA

Description

Prohibitin 2 (HGNC Symbol)

Entrez gene summary

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6965327 - 6970825

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000215021 (version 83.38)

Entrez gene

11331

UniProt

Q99623 (UniProt - Evidence at protein level)

neXtProt

NX_Q99623

Antibodypedia

PHB2 antibodies

PROTEIN BROWSER

PHB2-001
PHB2-003
PHB2-006
PHB2-008
PHB2-010
PHB2-012
PHB2-201
PHB2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHB2-001
ENSP00000441875
ENST00000535923
Q99623 [Direct mapping]
Prohibitin-2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007005 [mitochondrion organization]
GO:0007062 [sister chromatid cohesion]
GO:0008022 [protein C-terminus binding]
GO:0009986 [cell surface]
GO:0016363 [nuclear matrix]
GO:0030331 [estrogen receptor binding]
GO:0031536 [positive regulation of exit from mitosis]
GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway]
GO:0033218 [amide binding]
GO:0033600 [negative regulation of mammary gland epithelial cell proliferation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060744 [mammary gland branching involved in thelarche]
GO:0060749 [mammary gland alveolus development]
GO:0060762 [regulation of branching involved in mammary gland duct morphogenesis]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071944 [cell periphery]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
Show all
299 aa
33.3 kDa
No 0
PHB2-003
ENSP00000440317
ENST00000542912
F5GY37 [Direct mapping]
Prohibitin-2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
267 aa
29.7 kDa
No 0
PHB2-006
ENSP00000441662
ENST00000545167
F5GWA7 [Direct mapping]
Prohibitin-2
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
261 aa
29.2 kDa
No 0
PHB2-008
ENSP00000438634
ENST00000546111
F5H2D2 [Direct mapping]
Prohibitin-2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
87 aa
9.3 kDa
No 0
PHB2-010
ENSP00000475382
ENST00000545555
U3KPZ5 [Direct mapping]
Prohibitin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
103 aa
11.1 kDa
No 0
PHB2-012
ENSP00000439029
ENST00000536316
F5H3X6 [Direct mapping]
Prohibitin-2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
213 aa
23.6 kDa
No 0
PHB2-201
ENSP00000382362
ENST00000399433
J3KPX7 [Direct mapping]
Prohibitin-2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0016020 [membrane]
Show all
298 aa
33.2 kDa
No 0
PHB2-202
ENSP00000412856
ENST00000440277
Q99623 [Direct mapping]
Prohibitin-2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007005 [mitochondrion organization]
GO:0007062 [sister chromatid cohesion]
GO:0008022 [protein C-terminus binding]
GO:0009986 [cell surface]
GO:0016363 [nuclear matrix]
GO:0030331 [estrogen receptor binding]
GO:0031536 [positive regulation of exit from mitosis]
GO:0033218 [amide binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071944 [cell periphery]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
Show all
261 aa
29 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.