Expression of NPEPL1 in cancer - Summary - The Human Protein Atlas

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NPEPL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NPEPL1
Gene description	Aminopeptidase-like 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (MCF7)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA036356 , CAB004986 , CAB017025
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036356	CAB004986	CAB017025

GENE INFORMATION
Gene name	NPEPL1 (HGNC Symbol)
Synonyms	bA261P9.2, FLJ11583
Description	Aminopeptidase-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q13.32
Chromosome location (bp)	58689131 - 58719238
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000215440 (version 83.38)
Entrez gene	79716
UniProt	Q8NDH3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NDH3
Antibodypedia	NPEPL1 antibodies

PROTEIN BROWSER

NPEPL1-001	NPEPL1-002	NPEPL1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPEPL1-001 ENSP00000348395 ENST00000356091	Q8NDH3 [Direct mapping] Probable aminopeptidase NPEPL1 Show all	Enzymes Peptidases Metallopeptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008235 [metalloexopeptidase activity] GO:0030145 [manganese ion binding] Show all	523 aa 55.9 kDa	No	0
NPEPL1-002 ENSP00000437112 ENST00000525817	Q8NDH3 [Direct mapping] Probable aminopeptidase NPEPL1 Show all	Enzymes Peptidases Metallopeptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008235 [metalloexopeptidase activity] GO:0030145 [manganese ion binding] Show all	475 aa 50.5 kDa	No	0
NPEPL1-003 ENSP00000434810 ENST00000525967	Q8NDH3 [Direct mapping] Probable aminopeptidase NPEPL1 Show all	Enzymes Peptidases Metallopeptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008235 [metalloexopeptidase activity] GO:0030145 [manganese ion binding] Show all	495 aa 52.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.