Expression of DEFB116 in cancer - Summary - The Human Protein Atlas

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DEFB116

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DEFB116
Gene description	Defensin, beta 116
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

No evidence

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA047430
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047430

GENE INFORMATION
Gene name	DEFB116 (HGNC Symbol)
Synonyms	DEFB-16
Description	Defensin, beta 116 (HGNC Symbol)
Entrez gene summary	Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014]
Chromosome	20
Cytoband	q11.21
Chromosome location (bp)	31303212 - 31308585
Protein evidence	No evidence (all genes)
Ensembl	ENSG00000215545 (version 83.38)
Entrez gene	245930
UniProt	Q30KQ4 (UniProt - Inferred from homology)
neXtProt	NX_Q30KQ4
Antibodypedia	DEFB116 antibodies

PROTEIN BROWSER

DEFB116-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEFB116-001 ENSP00000383396 ENST00000400549	Q30KQ4 [Direct mapping] Beta-defensin 116 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0009986 [cell surface] GO:0042742 [defense response to bacterium] GO:0045087 [innate immune response] Show all	102 aa 11.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.