Expression of CELA3B in cancer - Summary - The Human Protein Atlas

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CELA3B

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CELA3B
Gene description	Chymotrypsin-like elastase family, member 3B
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (pancreatic cancer)
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Extracellular positivity in pancreas.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA045650
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045650

GENE INFORMATION
Gene name	CELA3B (HGNC Symbol)
Synonyms	CBPP, ELA3B
Description	Chymotrypsin-like elastase family, member 3B (HGNC Symbol)
Entrez gene summary	Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	21977021 - 21998642
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000219073 (version 83.38)
Entrez gene	23436
UniProt	P08861 (UniProt - Evidence at protein level)
neXtProt	NX_P08861
Antibodypedia	CELA3B antibodies

PROTEIN BROWSER

CELA3B-001	CELA3B-002	CELA3B-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CELA3B-001 ENSP00000338369 ENST00000337107	P08861 [Direct mapping] Chymotrypsin-like elastase family member 3B Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008203 [cholesterol metabolic process] GO:0008233 [peptidase activity] Show all	270 aa 29.3 kDa	Yes	0
CELA3B-002 ENSP00000363798 ENST00000374666	A0A0A0MRS2 [Direct mapping] Chymotrypsin-like elastase family member 3B Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	164 aa 17.4 kDa	No	0
CELA3B-004 ENSP00000383135 ENST00000400277	A0A0A0MSA6 [Direct mapping] Chymotrypsin-like elastase family member 3B Show all	Predicted intracellular proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	180 aa 19.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.