Expression of RNASEK in cancer - Summary - The Human Protein Atlas

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RNASEK

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNASEK
Gene description	Ribonuclease, RNase K
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044708
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044708

GENE INFORMATION
Gene name	RNASEK (HGNC Symbol)
Synonyms	MGC71993
Description	Ribonuclease, RNase K (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7012417 - 7014532
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000219200 (version 83.38)
Entrez gene	440400
UniProt	Q6P5S7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6P5S7
Antibodypedia	RNASEK antibodies

PROTEIN BROWSER

RNASEK-001	RNASEK-004	RNASEK-006	RNASEK-007	RNASEK-008	RNASEK-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNASEK-001 ENSP00000449500 ENST00000548577	Q6P5S7 [Direct mapping] Ribonuclease kappa Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004521 [endoribonuclease activity] GO:0005575 [cellular_component] GO:0009303 [rRNA transcription] GO:0016021 [integral component of membrane] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	137 aa 15.4 kDa	No	2
RNASEK-004 ENSP00000450174 ENST00000549393	H0YIU3 [Direct mapping] Ribonuclease kappa Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004521 [endoribonuclease activity] GO:0009303 [rRNA transcription] GO:0016021 [integral component of membrane] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	133 aa 15.4 kDa	No	1
RNASEK-006 ENSP00000449670 ENST00000552842	H0YIM4 [Direct mapping] Ribonuclease kappa Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all		46 aa 4.9 kDa	No	0
RNASEK-007 ENSP00000447359 ENST00000552039	A0A0C4DH85 [Direct mapping] Ribonuclease kappa Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004521 [endoribonuclease activity] GO:0009303 [rRNA transcription] GO:0016021 [integral component of membrane] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	71 aa 8.3 kDa	No	1
RNASEK-008 ENSP00000459471 ENST00000570898	A0A0C4DH85 [Direct mapping] Ribonuclease kappa Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004521 [endoribonuclease activity] GO:0009303 [rRNA transcription] GO:0016021 [integral component of membrane] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	71 aa 8.3 kDa	No	1
RNASEK-012 ENSP00000468923 ENST00000593646	A0A0C4DH89 [Direct mapping] Ribonuclease kappa Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004521 [endoribonuclease activity] GO:0009303 [rRNA transcription] GO:0016021 [integral component of membrane] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	98 aa 11 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.